Safety of MT-401-OTS in Patients With Relapsed AML or MDS
Status:
RECRUITING
Trial end date:
2029-09-01
Target enrollment:
Participant gender:
Summary
This study is a Phase 1 multicenter, open-label study evaluating the safety and efficacy of escalating doses of MT-401-OTS in 2 participant populations: 1) Those with intermediate or high-risk AML per 2022 ELN criteria who have evidence of MRD and/or \= 10% blast following prior induction therapy or at least 4 cycles of nonintensive therapy and 2) those with high- or very-high-risk MDS per 2023 IWG criteria and who have residual disease with \= 10% blasts following treatment with an HMA-based therapy.
Phase:
PHASE1
Details
Lead Sponsor:
Marker Therapeutics, Inc.
Collaborators:
City of Hope National Medical Center H. Lee Moffitt Cancer Center and Research Institute University of Kansas Medical Center