Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease

• Status: Completed
• Trial end date: 2017-11-20
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to show that the use of low volume iso-osmolar non-ionic radio contrast medium (30 cc) in a thoracic CT Scanning procedure in a selected group of patients with chronic kidney disease (CKD) will avoid contrast induced nephropathy (CIN) in comparison to a similar group of patients with CKD who receive no contrast medium..

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: VA Greater Los Angeles Healthcare System
• Collaborator: General Electric
• Treatments: Acetylcysteine; N-monoacetylcystine; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Subjects with documented stable Chronic Kidney Disease (CKD) defined as a stable eGFR 16-60 ml/min/m^2 for ≥ 12 months; and

• Referred to CT scanning procedure to evaluate pulmonary embolism, pulmonary malignancy, acute aortic syndromes, or renal artery stenosis.

Exclusion Criteria:

• CKD Stages 1, 2 and 5

• Stage 3-4 congestive heart failure (CHF)

• Irregular supraventricular tachycardia

• Allergic to iodinated Radio Contrast Medium (RCM)

• Allergic to Mucomyst

• Pregnancy

• Evidence of acute renal failure (ARF)

• Serum bicarbonate either less than 20 meq/L or greater than 35 meq/L

• Hydration with a bicarbonate solution is contraindicated or considered unsafe by the subject's caring physicians