PURPOSE: The purpose of this study is to determine whether transient opening of the
blood-brain barrier by pulsed ultrasound using the SonoCloud implantable ultrasound device is
safely tolerated in patients with recurrent glioblastoma immediately before systemic delivery
of carboplatin-based chemotherapy.
STUDY HYPOTHESIS: The blood-brain barrier can be safely opened using pulsed ultrasound prior
to chemotherapy administration in patients with recurrent glioblastoma. Transient opening of
the blood-brain barrier by pulsed ultrasound will increase the glioblastoma exposure to
carboplatin-based chemotherapy and increase progression-free and overall survival in patients
with recurrent glioblastoma.