Overview
Safety and Tolerance of Increased Doses of HRS-1780 Tablets in Healthy Subjects
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2023-06-30
2023-06-30
Target enrollment:
0
0
Participant gender:
Male
Male
Summary
This is a randomized, double-blind, placebo-controlled phase I clinical study. The primary objective is to evaluate the safety, tolerability, PK, and PD of single- and multiple-dose HRS-1780 in healthy subjects, and to evaluate the food effect on PK of HRS-1780.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Shandong Suncadia Medicine Co., Ltd.
Criteria
Inclusion Criteria:1. 18-45 years old (including boundary value, whichever is at the time of signing the
informed consent form), healthy male.
2. Weight ≥50 kg, body mass index (BMI = body mass/height square (kg/m2)) is in the range
of 18-28 (including boundary values)
3. Obtain informed consent before any activity related to the experiment begins, have a
full understanding of the purpose and significance of the experiment, and be willing
to comply with the test plan and dietary requirements.
4. Subjects (including partners) have no family planning within 3 months from the
beginning of the signing of the informed consent form to the last dose, and are
willing to adopt the efficient contraceptive measures stipulated in the program and
guarantee not to donate sperm.
Exclusion Criteria:
1. People with a history of hypertension.
2. People with severe systemic infectious diseases, serious trauma or major surgical
surgery before screening; those who plan to undergo surgery during the trial
3. There has been a history of clinical abnormal gastric emptying and severe chronic
gastrointestinal diseases.
4. Diseases found to show clinical significance before screening
5. Combined with diuretics before screening
6. Drugs were used 2 weeks before screening.
7. Laboratory or physical examination with any abnormalities and the researcher's
judgment is clinically significant.
8. 12-lead electrocardiogram is abnormal and of clinical significance
9. Positive for hepatitis B surface antigen, positive for hepatitis C antibody, positive
for syphilis spirochete antibody, positive for HIV antibody
10. People with severe allergic diseases or known or suspected of being allergic to any of
the ingredients in the research drug, allergic constitution (multiple drugs and food
allergies)
11. Participated in the clinical trial of any drug or medical device within the first 3
months of screening or planned to participate in the clinical trial of other drugs or
medical devices during the trial period (subject to the signing of informed consent)
12. Drink more than 14 units of alcohol per week in the first 6 months of screening; or
those who have taken alcohol products 48 hours before administration; or those who
have tested positive for alcohol exhalation during the baseline period.
13. Smoking more than 5 cigarettes a day in the 3 months before screening or using any
tobacco products 48 h before administration.
14. Drink/eat coffee, tea, grapefruit, chocolate or soft drinks, such as cola containing
methamphetrine (tein, caffeine or cocoaine) within 3 days before screening
15. Those who have had a history of drug abuse in the past five years or have used drugs
in the first three months of the trial; or urine drugs are screened positive
16. Blood donation ≥ 200 mL within 1 month before screening; or blood donation ≥ 400 mL
within 3 months before screening; or trauma or surgical surgery with blood donation
(plasma or platelets) or blood loss of ≥ 400 mL within 2 weeks
17. Inability tolerate venous puncture and blood collection or dizziness
18. Subjects who believe that there are other factors that are not suitable to participate
in this test