Safety and Tolerability of MK-5478 in Participants With Hypertension (5478-001)
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
This is a two part introductory clinical trial with MK-5478. Part I will evaluate the safety,
tolerability and pharmacokinetics and pharmacodynamics of MK-5478 in young, healthy males.
Part II will evaluate the safety, tolerability and pharmacodynamic effects of MK-5478 in
participants with hypertension. The primary hypothesis is that single oral doses of MK-5478
are sufficiently safe and well tolerated.