In Cambodia, falciparum is becoming more difficult to treat because drugs are becoming less
effective. The investigators can help to try to prevent the spread of this resistant malaria
by adding a drug that will make it more difficult for the mosquito to drink up the malaria in
people's blood. If the mosquito cannot drink up the malaria, then the malaria cannot develop
in the mosquito so it will not be able to inject malaria back into people when it bites. The
drug the investigators will use is called primaquine.
Primaquine commonly causes the red cells in the blood to break apart if they are weak. Red
cells need enzymes to work properly and weak red cells have low amounts of an enzyme called
glucose 6 phosphate dehydrogenase (G6PD). The investigators want to know if treating malaria
with primaquine will be safe for the red cells. To do this study, the investigators need to
know if a subject has low G6PD or not.
Phase:
Phase 4
Details
Lead Sponsor:
Malaria Consortium
Collaborators:
Centers for Disease Control and Prevention Institute Pasteur, Cambodia National Centre for Parasitology, Entomology and Malaria Control, Cambodia World Health Organization