Safety and Tolerability of Antioxidant (AT-001)for Reducing Brain Oxidative Stress
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the safety, bioavailability, and effectiveness of
an organic yeast-selenium compound in reducing brain oxidative stress. Oxidative stress in
the brain has been linked to a variety oif disorders including Alzheimer's disease. Selenium
is a very powerful antioxidant that could prove useful in reducing the harmful effects of
oxidative stress in the brain and may help prevent diseases such as Alzheimer's. Our recent
work has demonstrated that the specific type of selenium compound greatly influences it's
ability to enhance brain health and prevent Alzheimer changes in mouse models of this
disease.
This study will enroll 24 participants and will allow us to test the hypotheses that
yeast-selenium supplementation is safe in the elderly, and that our specific formulation
reduces brain oxidative stress.