Safety and Preliminary Efficacy of IVMED-80 Eye Drops in Keratoconus Patients
Status:
Completed
Trial end date:
2020-07-08
Target enrollment:
Participant gender:
Summary
We investigated the use of a copper sulfate eye drop (IVMED-80) for the treatment of
keratoconus. Preliminary laboratory data shows that the addition of copper sulfate increase
crosslinking of the structural proteins of the cornea thereby halting the progressing corneal
thinning and bulging seen in keratoconus. We conducted a Phase 1/2a study to evaluate the
safety and preliminary efficacy of a 6-week and a 16-week regimen using IVMED-80 and studied
its impact on ocular safety and the change/progression in patients' vision and clinical
measurements.