Safety and Pharmacokinetic Study of Y242 in Adult Subjects
Status:
Completed
Trial end date:
2013-02-01
Target enrollment:
Participant gender:
Summary
Obesity causes 600 premature deaths per week in the UK and existing treatments are not
effective. When humans eat, the bowels naturally secrete chemicals into the bloodstream which
make people feel full and which stop eating. One of these chemicals is known as Peptide YY
(PYY). The investigators have previously shown that injections of PYY reduce appetite and
food intake in human volunteers. The investigators have now developed a very similar
chemical, Y242, as a treatment for obesity. Y242 has been tested in animals and has been
shown to be safe, to reduce their appetite, and to last for much longer than PYY itself. This
study will test Y242 to ensure that it is well tolerated in humans, and to see how long it
lasts in the blood stream after being injected under the skin. It will also look for any
effects on appetite.