Safety and Feasibility of Electrochemotherapy in Unresectable Colorectal Adenocarninoma Liver Metastases
Status:
Terminated
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
Electrochemotherapy (ECT) is a non-thermal tumour ablation modality. It consists of the local
potentiation, by means of local reversible electroporation of tumour tissues, of the
antitumor activity of non-permeant or poorly permeant anticancer drugs already possessing
intrinsic cytotoxicity. ECT has proved to be effective in the treatment of various cutaneous
tumour nodules of any origin. Mostly ECT is offered to patients in case of multiple cutaneous
metastases, when they cannot be excised, due to their number or localization. This study
investigate the application of ECT in the treatment of liver metastases from colorectal
adenocarcinoma, for which other thermal cytoreductive methods would be risky compared to the
supposed expected clinical benefits.