Safety and Efficiency Study of Loading Dose Atorvastatin in Cardiac Surgery
Status:
Completed
Trial end date:
2013-07-01
Target enrollment:
Participant gender:
Summary
Statins were reported to have pleiotropic effects including antiinflammatory, anti-oxidative
stress effects and stabilise plaque in some conditions. Some researches indicate loading dose
statin can reduce contrast induced nephropathy, and the levels of inflammatory markers were
significantly decreased. The investigators hypothesis loading dose atorvastatin may attenuate
inflammatory response during cardiopulmonary bypass (CPB) and therefore reduce postoperative
acute kidney injury in cardiac surgery.
Phase:
N/A
Details
Lead Sponsor:
Peking Union Medical College
Collaborator:
Chinese Academy of Medical Sciences, Fuwai Hospital