Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry Eye
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Thymosin Beta 4 (Tβ4) is a synthetic copy of the naturally-occurring 43-amino acid peptide
that is found in a variety of tissues. Tβ4 promotes/accelerates wound repair in dermal,
ocular, and cardiac animal models. Two recent pre-clinical evaluations have demonstrated that
Tβ4 promotes corneal ocular surface defects healing in animal models of dry eye. RGN-259
(formulation of Tβ4 ophthalmic solution) mechanism of action offers potential to be a product
that meets a major unmet medical need in patients with dry eye.