Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata

• Status: Completed
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Systemic Pulse Glucocorticoids have been shown to be effective in widespread Alopecia areata but not the totalis, universalis or ophiasic type. Whether the failure is due to inadequate dosing, inadequate frequency or other factors is a matter of debate. The investigators decided to conduct this study using the oral pulse steroid, however with higher doses and more frequent pulses to patients with severe forms of Alopecia areata.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: King Saud University
• Collaborator: Saudi Society of Dermatology and Dermatologic surgery
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Alopecia Universalis

• Alopecia Totalis

• Ophiasic Alopecia

Exclusion Criteria:

• diabetes mellitus

• peptic ulcer

• hypertension

• infection

• psychosis

• heart disease

• kidney disease

• endocrine disorders (apart from a subclinical hypothyroidism and autoimmune thyroiditis)

• received systemic or topical treatment within the last 4 weeks before enrollment

• pregnancy