Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
Status:
Completed
Trial end date:
2004-05-01
Target enrollment:
Participant gender:
Summary
Normally, nerve fibers carry electrical impulses through the spinal cord, providing
communication between the brain and the arms and legs. In people with spinal cord injury,
some fibers may be destroyed at the site of injury, while others remain connected but do not
work correctly to carry electrical impulses. As a result, subjects with an incomplete spinal
cord injury may have spasticity which is muscle spasms or muscle stiffness that makes
movement difficult. Fampridine-SR is an experimental drug that increases the ability of the
nerve to conduct electrical impulses. This study will examine the effects of Fampridine-SR on
moderate to severe lower-limb spasticity, as well as the effects on bodily functions such as
bladder control, bowel function and sexual function. The study will also examine the possible
risks of taking Fampridine-SR.