Safety and Efficacy of Infliximab in Palmoplantar Psoriasis
Status:
Completed
Trial end date:
2009-07-01
Target enrollment:
Participant gender:
Summary
Palmoplantar psoriasis is a variant of psoriasis affecting palms and soles. It is one of the
most debilitating variants of psoriasis which very often interferes with daily activities and
with the ability to work. This type of psoriasis is very difficult to treat as topicals have
difficulty penetrating the thick epidermis of palms and soles and are therefore not very
effective. The response to standard agents (methotrexate, cyclosporine and acitretin) is also
usually limited. A number of these patients have very severe hand and feet disease with mild
to no involvement elsewhere on the body.
Given the efficacy of infliximab in psoriasis, the purpose of this study is to evaluate if
infliximab is safe and if it will improve severity and quality of life in patients with
palmoplantar psoriasis, a debilitating variant of psoriasis.