Safety and Efficacy of Imatinib in Chronic Myelogenous Patients Older Than 70 Years

• Status: Completed
• Trial end date: 2007-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this phase II trial is asses the tolerability and the effectiveness of imatinib in patients with chronic myelogenous leukemia in chronic phase with age more than 70, diagnosis of cml is being performed within 1 year. Quality of life will be carefully assessed.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Poitiers University Hospital
• Collaborator: Novartis
• Treatments: Imatinib Mesylate

Criteria

Inclusion Criteria:

• CML Ph+ (assessed by cytogenetic or FISH)

• Chronic phase with less than 5% bone marrow blasts

• Diagnosis within 12 months

• Age ≥ 70 year at inclusion

• PS grade 0 to 2 (ECOG)

• Mini mental status more than 25

• Hydroxyurea optional before Imatinib

• Adequate end organ function, defined as the following: total bilirubin <1.5x uln, sgpt <3x uln, creatinine <1.5x uln.

Exclusion Criteria:

• patients who cannot sign an informed consent indicating that they are aware of the investigational nature of this study in keeping with the policies of the hospital

• Mini mental status ≤ 25

• patients who are not able to adequately take the study drug

• Age less than 70 y

• accelerated or blastic phase

• previous therapy with imatinib or interferon

• HIV positivity