Safety and Efficacy of Allogeneic MSCs in Promoting T-regulatory Cells in Patients With Small Abdominal Aortic Aneurysms
Status:
Terminated
Trial end date:
2021-09-30
Target enrollment:
Participant gender:
Summary
This project is to determine the safety and explore the effectiveness of allogeneic (not
cells of the participant but those of another human) mesenchymal stromal cells (MSCs) in
decreasing inflammation and possible enlargement of the participants' abdominal aortic
aneurysm. Participants will be selected as a possible subject because of an abdominal aortic
aneurysm discovered on the ultrasound or computed tomographic ("CT") scan requested by the
participants' doctor.
The purpose of this study is to collect information that will be used to determine if MSCs
can be used to decrease inflammation and possibly slow down enlargement of the participants'
aneurysm. The investigators will also be collecting blood samples to study special
inflammatory cells that cause aneurysms as well as asking participants to have a "PET"
(positron emission tomography) scan that can measure inflammation directly in the
participants' aneurysm.