Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether treatment with esomeprazole for 6 months will improve asthma in adult patients with moderate to severe asthma and symptoms of gastroesophageal reflux disease.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: AstraZeneca
• Treatments: Anti-Asthmatic Agents; Esomeprazole

Criteria

Inclusion Criteria:

• Adults with diagnosis of asthma since at least 6 months.

• Symptoms of asthma during run-in.

• At least 3 months history and present symptoms of 1 or more of the following: burning feeling behind breastbone, pain behind breastbone, acid taste in the mouth.

Exclusion Criteria:

• Patients with clinically relevant abnormalities.

• Patients with a smoking history of ≥10 pack-year.

• Patients who have had previous surgery on the esophagus or the stomach.