Safety and Efficacy Study of Nitric Oxide in Patients Going Through Lung Transplantation

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the safety and efficacy of inhaled nitric oxide in prevention of lung graft dysfunction due to ischemia-reperfusion

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mallinckrodt
• Treatments: Nitric Oxide

Criteria

Inclusion Criteria:

• Have a lung graft scheduled

• Males and females aged 18 to 65

• Signed informed consent approved by the IRB/EC

Exclusion Criteria:

• Uncontrolled bacterial infection

• Creatinine clearance <50 ml/min

• Severe extrapulmonary organic dysfunction

• Continuing smoking habit

• Neoplastic disease (2-5 years free of tumor, depending on type)

• Pregnancy or nursing

• Severe osteoporosis

• Active peptic ulcer

• Progressive neuromuscular disease

• Active limiting systemic disease. Complicated diabetes.

• Any contraindication based on the judgement of the investigator