Safety and Efficacy Study of Hydromorphone and Morphine

• Status: Completed
• Trial end date: 2005-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare a standard weight-based dose of intravenous (IV) hydromorphone (Dilaudid) to a standard weight-based dose of IV morphine in adults presenting to the Emergency Department (ED) with acute severe pain.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Chang, Andrew, M.D.; Montefiore Medical Center
• Treatments: Hydromorphone; Morphine

Criteria

Inclusion Criteria:

• adults between the ages of 21 and 65 who presented to the ED with acute pain (defined as pain less than 7 days in duration) (23) of sufficient severity in the judgment of the ED attending to warrant use of IV opioids.

Exclusion Criteria:

• previous allergy to morphine or hydromorphone

• systolic blood pressure less than 90 mmHg

• alcohol intoxication as judged by the attending physician

• use of other opioids within the past 7 days

• use of an Monoamine Oxidase (MAO) inhibitor

• chronic pain syndromes (such as sickle cell disease or fibromyalgia)