Safety and Efficacy Study of Glufosfamide in Previously Treated Advanced Soft Tissue Sarcoma
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
Primary Objective:
1. To evaluate the efficacy of glufosfamide in subjects with advanced soft tissue sarcoma as
measured by objective response rate
Secondary Objectives:
1. To evaluate the efficacy of glufosfamide in subjects with advanced soft tissue sarcoma
as measured by duration of response, progression-free survival and overall survival
2. To evaluate the safety of glufosfamide in subjects with advanced soft tissue sarcoma
Exploratory Objectives:
1. To evaluate the biological effect of glufosfamide on the metabolic profile in subjects
with advanced soft tissue sarcomas, as determined by FDG-PET
2. To correlate efficacy endpoints with expression of tumor-associated glucose transporter
proteins