Safety and Efficacy Study of Glufosfamide in Ovarian Cancer
Status:
Terminated
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
Primary Objectives:
- To evaluate the effect of glufosfamide on the serum concentrations of CA125 in subjects
with ovarian cancer
- To evaluate the safety of weekly glufosfamide dosing in subjects with ovarian cancer as
compared with every 21-day dosing
Secondary objectives:
- To evaluate the efficacy of glufosfamide in subjects with ovarian cancer as measured by
objective response rate, duration of response, progression-free survival, and overall
survival
- To evaluate the pharmacokinetics of glufosfamide and isophosphoramide mustard during and
after treatment
Exploratory objective:
- To correlate efficacy endpoints with expression of tumor-associated glucose transporter
proteins