Overview

Safety and Efficacy Study of Eribulin in Combination With Bevacizumab for Second-line Treatment HER2- MBC Patients

Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
0
Participant gender:
Female
Summary
In the second-line treatment setting for MBC, many agents, including antitubulin drugs (Taxanes, Vinorelbine) and antimetabolites (Capecitabine, Gemcitabine), have demonstrated activity, but no agent is clearly superior. Although some combinations of cytotoxic agents provide a small progression-free survival advantage, none has demonstrated an OS advantage, and toxicity is generally greater than for single agents. At present, there is no standard for this treatment setting. New treatments that could delay disease progression without systemic toxicity would represent a significant advancement.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Consorzio Oncotech
Collaborator:
Clinical Research Technology S.r.l.
Treatments:
Bevacizumab
Criteria
Inclusion Criteria:

- Signed informed consent prior to initiation of any study-specific procedures or
treatment, as confirmation of the patient's awareness and willingness to comply with
the study requirements.

- Female patients ≥18 years of age.

- Histologically confirmed Human Epidermal Growth Factor Receptor 2-Negative
adenocarcinoma of the breast with documented progression of disease per investigator
assessment following or during first-line treatment with Bevacizumab in combination
with Paclitaxel for MBC; patients can have measurable or non-measurable disease. A
minimum of 4 cycles of Bevacizumab 15 mg/kg or 6 cycles 10 mg/kg received in the
first-line setting.

- Patients must have received Bevacizumab in combination with Paclitaxel as first line
treatment. As part of their first line maintenance treatment, patients may have
received:

- Bevacizumab monotherapy

- Bevacizumab in combination with endocrine treatment

- Nothing (for a period ≤ 6 weeks from the last Bevacizumab treatment)

- ECOG performance status (PS) of 0-2.

- At least 28 days since prior radiation therapy or surgery and recovery from treatment.

- Patients must have measurable disease which must be evaluable per RECIST v1.1.

- Estimated life expectancy of ≥12 weeks.

Exclusion Criteria:

Disease-specific exclusions

- Patients who have received anti-angiogenic therapy [e.g. tyrosine kinase inhibitors
(TKIs) or anti-vascular endothelial growth factors (anti-VEGFs)] other than
Bevacizumab for the first-line treatment of MBC.

- Patients who have exclusively received endocrine treatment in combination with
Bevacizumab until the first progression.

- Positive or unknown Human Epidermal Growth Factor Receptor 2/neu status or for whom
determination of Human Epidermal Growth Factor Receptor 2 status is not possible. In
general, Human Epidermal Growth Factor Receptor 2 positive status will be identified
by a FISH assay as evaluated at the institution, or, if FISH is unavailable, a 2+ or
3+ immunohistochemistry result (but method of identification may vary by region or
institution).

- Current, recent (within 4 weeks or 2 half-lives, whichever is greater, before day 1)
or planned participation in an experimental drug study - other than a Bevacizumab
breast cancer study.

- Active malignancy, other than superficial basal cell and superficial squamous (skin)
cell, or carcinoma in situ of the cervix or breast within the last 5 years.

- Any laboratory values at baseline as described in the protocol;

- Psychiatric or addictive disorders or other conditions that, in the opinion of the
investigator, would prevent the patient from meeting the study requirements.

- Serious active infection requiring i.v. antibiotics and/or hospitalization at study
entry.

- Patients who are treated with any medicinal product that contraindicates the use of
any of the study drugs, may interfere with the planned treatment, affects patient
compliance or puts the patient at high risk for treatment-related complications.

Bevacizumab-specific exclusions: (see protocol)

Eribulin-specific exclusions: (see protocol)