Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL)

• Status: Terminated
• Trial end date: 2017-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The corneal collagen cross linking is currently used in the treatment of keratoconus but this procedure has also a sterilizing non-specific effect on bacteria and fungus. So the corneal cross linking in association with the antibiotic treatment could result in a reduction of the duration of epithelial complete healing of the cornea.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nantes University Hospital
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Riboflavin

Criteria

Inclusion Criteria:

• Infectious bacterial or fungal keratitis with : size > 2mm or within the central corneal area ( 3mm of the visual axis ) or with a reaction in anterior chamber.

• Being major responsible.

• Agreement in writing to participate in the study.

• Being affiliated to a national insurance scheme.

Exclusion Criteria:

• Present an infectious keratitis without all the previous criteria.

• Herpes or acanthamoeba keratitis

• preperforated or perforated cornea.

General criteria:

• Pregnant woman.

• Minors(miners).

• Adults under guardianship.

• Patient can not be followed during 3 necessary months.

• French speaking patient.

• Unaffiliated patient in a national insurance scheme.

• HIV infected patients