Overview Safety and Effectiveness of S-adenosyl-l-methionine (SAMe) for the Treatment of Major Depression Status: Completed Trial end date: 2010-06-01 Target enrollment: Participant gender: Summary The purpose of this study is to determine the safety and effectiveness of s-adenosyl-l-methionine (SAMe) in treating major depression. Phase: N/A Details Lead Sponsor: Maurizio Fava, MDCollaborator: National Center for Complementary and Integrative Health (NCCIH)Treatments: CitalopramDexetimide