Safety and Effectiveness of Giving Isotretinoin to HIV-Infected Women to Treat Cervical Tumors
Status:
Completed
Trial end date:
2001-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to see if it is safe and effective to give isotretinoin to
HIV-infected women with cervical tumors to prevent these tumors from becoming cancerous.
Cervical tumors are found in both HIV-infected and HIV-negative women. However, HIV-infected
women are at a greater risk, and often their tumors become cancerous more quickly than those
in HIV-negative women. Isotretinoin may be able to prevent this from happening. However,
since these tumors tend to disappear over time, many doctors are hesitant to give their
patients isotretinoin since this drug causes birth defects. This study looks at whether it is
better to treat cervical tumors in HIV-infected women or to wait and see if they will
disappear by themselves.
Phase:
Phase 3
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)