Safety, Tolerability and Pharmacokinetics of Oral Tablet of Irinotecan in Adult Patients With Solid Tumors
Status:
Completed
Trial end date:
2018-10-30
Target enrollment:
Participant gender:
Summary
This study evaluates the safety, tolerability and pharmacokinetics of oral administration of
irinotecan in adult patients. Oral irinotecan will be administered as monotherapy in a dose
escalation trial to establish the Maximal Tolerated Dose. Totally 25 patients will be treated
with irinotecan tablets as mono-therapy. As an extension trial 12 patients will be treated
with oral irinotecan in combination with oral capecitabine