Safety Study of the Inhibition of Agouti-related Protein (AgRP) for the Management of Obesity and Weight Loss
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Multiple pathways including peripheral and central hormones and neurotransmitters are
involved in the regulation of food intake and body weight. One of the most studied pathways
involves the melanocortin receptor. Agouti-related protein (AgRP) and alpha-melanocyte
stimulating hormone (alphaMSH)have been shown to play an integral role in food intake and
body weight.
It is reasonable to speculate that if there is an imbalance of alphaMSH and AgRP exist in
obese individuals and inhibiting the activity of AgRP may be of therapeutic benefit in
treating obesity.