Safety Study of the Chemotherapy Modulator PHY906 in Patients With Advanced Colorectal Cancer
Status:
Terminated
Trial end date:
2003-03-01
Target enrollment:
Participant gender:
Summary
The triple combination chemotherapy of irinotecan, 5-fluorouracil and leucovorin
(CPT-11/5-FU/LV or Saltz regimen) is the treatment of choice for patients with advanced
colorectal cancer. Severe diarrhea, unfortunately, is a side effect of such treatment.
Preclinical studies have indicated that the botanical drug PHY906 can reduce such diarrhea
without compromising the effectiveness of the chemotherapy. The primary purpose of this
clinical study is to evaluate the safety, tolerability and minimum effective dose of PHY906
when administered in conjunction with the Saltz regimen.