Safety Study of a Long-Acting Injectable Steroid to Treat Knee Osteoarthritis
Status:
Completed
Trial end date:
2017-12-28
Target enrollment:
Participant gender:
Summary
The main purpose of this study is to understand the pharmacokinetics of EP-104IAR and to
determine whether it is safe to use in patients with osteoarthritis (OA) of the knee. The
study will also provide some preliminary insights into whether the experimental treatment
reduces pain in the knee.
Osteoarthritis is the most common joint disease, affecting over 20 million people in the US
alone. Currently, pain treatments that are injected directly into the knee often work for
only a short time and may also have side effects within the rest of the body. The
experimental treatment is a steroid that is in the same family of drugs as the most common
current injectable treatments for knee osteoarthritis. For this study, the drug is coated
with a polymer intended to prolong the time it stays inside the knee and lessen potential
side effects.