Safety Study of a Dual Anti-HIV Gene Transfer Construct to Treat HIV-1 Infection
Status:
Completed
Trial end date:
2017-11-01
Target enrollment:
Participant gender:
Summary
This is an early phase research study looking at whether an experimental gene transfer,
LVsh5/C46 (also known as Cal-1), is safe and if it can protect the immune system from the
effects of HIV without the use of antiretroviral drugs.
Cal-1 is an experimental gene transfer agent designed to inhibit HIV infection through 2
active parts:
1. Removing a protein named CCR5 from bone marrow and white blood cells
2. Producing a protein named C46 on bone marrow and white blood cells