Safety Study of Ibuprofen to Treat Acute Traumatic Spinal Cord Injury
Status:
Completed
Trial end date:
2017-09-01
Target enrollment:
Participant gender:
Summary
The Ibuprofen - Spinal Cord Injury (SCI) - Safety trial investigates tolerability and
feasibility of "small molecule" (Ibuprofen) mediated Rho-inhibition as putative
neuroprotective, plasticity-enhancing and neurorestaurative intervention. The primary safety
analysis is based on the incidence of severe gastrointestinal bleedings. In addition, the
feasibility of recruitment procedure, and oral administration of the compound within the
multidisciplinary setting of acute intensive medical care will be explored. Furthermore, the
pharmacokinetics of Ibuprofen under the condition of acute motor complete SCI will be
investigated. Secondary endpoints will permit preliminary statements about effects on
neuropathic pain, spasticity, and neurological function.