Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant
Status:
Active, not recruiting
Trial end date:
2032-11-01
Target enrollment:
Participant gender:
Summary
This study will evaluate patients with blood cell cancers who are going to have an allogeneic
(donor) blood stem cell transplant from a partially matched relative. The research study will
test whether immune cells, called T cells, which come from the donor relative and are
specially grown in the laboratory and then given back to the patient along with the stem cell
transplant (T cell addback), can help the immune system recover faster after the transplant.
As a safety measure, these T cells have been "programmed" with a "self-destruct switch" so
that if, after they have been given to the patient, the T cells start to react against the
tissues (called "graft versus host" disease, GVHD), the T cells can be destroyed.