Safety Study of Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS)
Status:
Completed
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
This study is a pilot two- center study to determine if aztreonam lysine for inhalation AZLI
can be safely and self-administered in lung transplant recipients with newly diagnosed
bronchiolitis obliterans syndrome, grade 1 (BOS) and obtain pilot data regarding its effect
on lung function in order to appropriately design and power a larger multicenter randomized
study.
The hypothesis is that AZLI is a safe and effective treatment for declining lung function in
lung transplant recipients with early stage BOS.