Overview
Safety Study of 90Y-hMN14 to Treat Colorectal Cancer Patients With Limited Residual Disease After Surgery
Status:
Terminated
Terminated
Trial end date:
1969-12-31
1969-12-31
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this trial is to determine the safety of 90Y-hMN14 at different dose levels in the treatment of residual colorectal cancer following recent surgery.Phase:
Phase 1Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Gilead Sciences
Immunomedics, Inc.Treatments:
Labetuzumab
Criteria
Disease Characteristics:- Patients with documented histologic and cytologic diagnosis of colon or rectal
malignancy
- Patients with documented status post surgical resection of primary cancer or
metastases
- Limited residual disease (i.e., CEA serum levels < 15 ng/mL and negative baseline CT
scans, or no lesion > 1 cm)
Prior/Concurrent Therapy:
- Patients must have completed chemotherapeutic agents, biologic therapy, radiotherapy,
other investigational therapy for cancer, or surgical procedures at least six weeks
prior to study entry.
- Patients must have recuperated from surgery and toxicities (as a result of previous
therapy) sufficiently prior to study entry
- Biologic Therapy: Patients who have received a murine, chimeric, CDR-grafted
(humanized), or human IgG will be eligible provided pre-study evaluations demonstrate
no significant reactivity with hMN-14 IgG (i.e., HAHA)
- Radiotherapy: No prior external beam irradiation to a field that includes more than
30% of the red marrow. No prior radiation to maximal tolerable levels for any critical
organs (e.g., 3000 cGy for the liver; 2000 cGy for the lungs and kidneys)
Patient Characteristics/Inclusion Criteria:
- Performance Status: Patients with Karnofsky performance status > 70%
- Hematopoietic: ANC >/= 1.5 x 10/L; Hemoglobin >/= 10 g/dL; Platelets >/= 100 x 10/L
- Renal: Serum Creatinine = 1.5 x ULN
- Hepatic: Serum Bilirubin = 1.5 ULN; AST and ALT = 2.5 x ULN; Alk Phosphatase =
2.5 x ULN
- Cardiovascular: Patients with LVEF >/= 50% by required MUGA/2D-ECHO tests
- Pulmonary: Patients with DF and FEV1 >/= 60% by required Pulmonary Function Tests
- Central Nervous System: Patients with known metastatic disease to the CNS are
excluded.
- Other: Patients agreeing to use a medically effective method of contraception during
and for a period of three months after the treatment period. A pregnancy test will be
preformed on each premenopausal female of childbearing potential immediately prior to
entry into study. Patients must understand and give written informed consent.