Safety Assessment of Potential Interactions Between IV Methamphetamine and Osmotic-Release Methylphenidate (OROS-MPH)
Status:
Completed
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
This is a human inpatient clinical pharmacology study to assess potential interactions
between intravenous (i.v.) methamphetamine infusion and oral osmotic release methylphenidate
(OROS-MPH). The primary objective of this study is to determine the safety of the OROS-MPH
concurrent with i.v. d-methamphetamine infusions of 15 mg and 30 mg. Safety outcome measures
include cardiovascular responses [heart rate (HR), blood pressure (BP), and
electrocardiograph (ECG) measurements], oral temperature, adverse events (AEs), and clinical
laboratory analyses.