SWOG-9321 Melphalan, TBI, and Transplant vs Combo Chemo in Untreated Myeloma
Status:
Completed
Trial end date:
2006-11-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer
cells. Combining chemotherapy and radiation therapy with peripheral stem cell transplantation
may allow the doctor to give higher doses of chemotherapy and radiation therapy and kill more
cancer cells. It is not yet known which treatment regimen is more effective for multiple
myeloma.
PURPOSE: Randomized phase III trial to compare the effectiveness of melphalan, total-body
irradiation, and peripheral stem cell transplantation with that of combination chemotherapy
in treating patients who have previously untreated multiple myeloma.
Phase:
Phase 3
Details
Lead Sponsor:
Southwest Oncology Group
Collaborators:
Cancer and Leukemia Group B Eastern Cooperative Oncology Group National Cancer Institute (NCI)