The main purpose of this study is to determine whether hippocampal synaptic vesicle density
estimated by hippocampal [11C]APP-311/[11C]UCB-J binding in individuals diagnosed with
cannabis use disorder (CUDs) improves with at least 4 weeks of confirmed abstinence from
cannabis, in comparison to healthy controls (HCs). Furthermore, any change in synaptic
vesicle density will be placed in functional context by measuring verbal memory, which is
sensitive to hippocampal function, before and after at least 4 weeks of confirmed abstinence.
Finally, the relationship between hippocampal [11C]UCB-J binding in CUDs with measures of
cannabis exposure (e.g., age of initiation, cumulative lifetime dose) will be explored.