We hypothesize that melatonin as compared to PPI and to placebo, improves GERD symptoms by
decreasing esophageal acid exposure and esophageal acid sensitivity in GERD. We hypothesize
that melatonin as compared to PPI and to placebo reduce the frequency and duration of
transient lower esophageal sphincter relaxations (TLESRs). In addition we hypothesize that
melatonin as compared to PPI and to placebo improves quality of life and quality of sleep of
GERD patients.