STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse

• Status: Completed
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if having an alcohol use disorder affects recovery from depression, and also whether recovery from depression in patients who have alcohol use disorders is also accompanied by improvement in the alcohol use disorder.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: New York State Psychiatric Institute
• Collaborator: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Treatments: Citalopram; Dexetimide; Ethanol

Criteria

Inclusion Criteria:

• Males and females aged 18- 75 years

• Meets criteria for Non-psychotic Major Depression

• Signs informed consent and able to comply with study

• Hamilton Depression Scale (HAM-D 17) >14

• Endorses any drinking items on Short Michigan Alcoholism Screening Test

Exclusion Criteria:

• Pregnant women and women of childbearing potential who are not using a medically accepted means of contraception.

• Women who are breast feeding

• Patients with suicidal ideation that require hospitalization

• Patients with unstable physical disorders

• Patients with a history of allergy to citalopram or history of non-response to an adequate dose of citalopram in the current episode.

• Patients meeting criteria for the following diagnoses as a primary condition:

Schizophrenia, Schizoaffective Disorder, Bipolar I, II, and Not Otherwise Specified, Anorexia nervosa, Bulimia, Obsessive Compulsive Disorder

• Patients abusing substances which require detoxification. American Society for Addiction Medicine standards for detoxification will be used (Level III.7). Patients with substance abuse who are in substance abuse treatment will be eligible.