SPME For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver Transplantation
Status:
Completed
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
Standard anesthetic management of liver transplantation patients includes a general
anesthetic using multiple drugs, including the neuromuscular relaxant rocuronium.
Pharmacokinetic modelling of this agent has been poorly described during liver
transplantation, which impacts on appropriate dosing of this agent within this population
where plasma concentrations can vary with fluid shifts and hepatic drug metabolism during the
various phases of liver transplantation. Plasma drug and drug metabolite concentrations will
be measured using the technique of solid phase micro-extraction (SPME). Measuring and
correlating the levels of rocuronium and other liver metabolites with the degree of post
transplantation hepatic dysfunction may serve as a simple and cost-effective marker to aid
diagnosis, identify those at risk of hepatic dysfunction and potentially grade the severity