Overview

SINUS WASH Pilot Study in Adults Testing Positive for COVID-19

Status:
Recruiting
Trial end date:
2022-03-01
Target enrollment:
0
Participant gender:
All
Summary
COVID-19 is highly infectious and transmission of the virus is thought to be similar to that of influenza which can be transferred through droplets released when a person coughs, sneezes or talks. Studies have shown that nasal rinsing and mouth washes may be an important way to deliver treatments that could reduce the amount of a virus that is present in the nose and mouth. This also could mean that there is less virus available to pass on to others. We want to see if the use of nose rinses and mouth washes using Povidone-Iodine will reduce the the amount of virus in the nose and throat of people who have tested positive for COVID-19 disease and also reduce the spread of infection within their household.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Hampshire Hospitals NHS Foundation Trust
Treatments:
Povidone
Povidone-Iodine
Criteria
Inclusion Criteria:

- Healthcare worker OR patient on a general ward who has had a positive COVID-19 test OR
a person who is co-residing with an affected staff member or patient who is now at
home in self-isolation.

- capable of giving informed consent

- able to self-administer the sinus rinses and mouth washes

- able to have healthcare professional-led swabs OR self-administer the oral and
nasopharyngeal swabs

- aged 18 years and over.

Exclusion Criteria:

- not capable of giving informed consent

- unable to self-administer the sinus rinses and mouth washes

- unable to have healthcare professional-led swabs OR self-administer the oral, nasal
and/OR nasopharyngeal swabs

- unable to send swabs to the study team via the approved methods described in
participant information leaflet and protocol

- under 18 years of age.

- known hypersensitivity to Iodine

- at risk of aspiration due to an unsafe swallow

- hyperthyroidism or other manifest thyroid diseases

- herpetiform dermatitis (Duhring's disease)

- planned or undergoing radioiodine treatment

- actively Breastfeeding

- pregnant