The purpose of the study is to investigate if use of simvastatin is associated with the level
of oxidative stress in humans. The association is examined by comparing changes in oxidative
stress in a group treated with simvastatin with the change in a placebo group. The study is a
randomized-based, double-blinded placebo-controlled study. Each treatment group consists of
20 healthy male volunteers who consume simvastatin or placebo over 14 days. The induction of
oxidative stress is measured by 8-oxoguanosine and 8- oxodeoxyguanosine, isolated from urine.
A t-test will be performed to compare drug treatment with placebo. The results will be
published.
Phase:
Phase 2
Details
Lead Sponsor:
Rigshospitalet, Denmark
Collaborators:
Klinisk Biokemisk Afdeling Klinisk farmakologisk Afdeling Sektion for Biomedicin Institut for Veterinær Patobiologi