SHORT- AND LONG TERM ANTIBACTERIAL EFFECTS OF A SINGLE RINSE WITH DIFFERENT MOUTHWASHES: A RANDOMIZED CLINICAL TRIAL

• Status: Completed
• Trial end date: 2020-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Objectives: To reduce the microbial level in the aerosol created during dental procedures is essential in avoiding infections. The aim of this study was to examine the change of Streptococcus mutans (S. mutans) and the total bacterial load in human saliva in vivo after a single rinse with different mouthwashes.

Material and methods: One mL unstimulated saliva was collected from volunteers with poor oral hygiene at baseline and 5 min after a one-min rinsing with Solumium Oral® (hyper-pure 0.0015% chlorine dioxide; ClO2), Listerine Total Care®, Corsodyl® (0.2% chlorhexidine-digluconate; CHX), or BioGate Si*CLEAN for bacterial investigation. In a second study volunteers rinsed with 0.003% ClO2 or CHX for one-min and saliva was collected at baseline, after 5 and 90 min. After plating the total plate and S. mutans colony numbers were determined.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Semmelweis University
• Collaborators: Department of Medical Microbiology, Semmelweis University; Department of Pedodontics and Orthodontics, Semmelweis University; Institute of Digital Health Sciences, Semmelweis University; University Pharmacy Department of Pharmacy Administration, Semmelweis University
• Treatments: Chlorhexidine; Chlorine dioxide; Fluorides; Sodium Fluoride

Criteria

Inclusion Criteria: DMF≥10, minimum 5 active caries and PSR≥2 -

Exclusion Criteria: smoking, a history of antibiotic, or probiotic use 3 months prior to sampling, or known allergy to any of the ingredients of mouthwashes being tested

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