Overview

SGM-101 in Colorectal Brain Metastases.

Status:
Not yet recruiting
Trial end date:
2022-12-01
Target enrollment:
0
Participant gender:
All
Summary
This study assesses the feasibility of SGM-101, a fluorochrome-labeled anti-carcinoembryonic antigen monoclonal antibody, for intraoperative near-infrared fluorescence imaging of colorectal brain metastases by injecting SGM-101 intravenously 3 - 5 days prior to surgery.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Leiden University Medical Center
Collaborators:
Medical Center Haaglanden
Surgimab
Criteria
Inclusion Criteria:

1. Signed informed consent prior to any study-mandated procedure;

2. Patients aged over 18 years old;

3. All women of child bearing potential and all males must practice effective
contraception during the study and be willing and able to continue contraception for
at least 30 days after their last dose of study treatment.

4. Has the ability to communicate well with the Investigator in the Dutch language and
willing to comply with the study restrictions.

5. Diagnosed with brain metastasis of colorectal origin and scheduled for a resection.

Exclusion Criteria:

1. History of any anaphylactic reaction;

2. Previous use of SGM-101;

3. Other malignancies either currently active or diagnosed in the last 5 years, except
adequately treated in situ carcinoma of the cervix and basal or squamous cell skin
carcinoma;

4. Laboratory abnormalities defined as:

1. Aspartate AminoTransferase, Alanine AminoTransferase, Gamma Glutamyl Transferase)
or Alkaline Phosphatase levels above 5 times the or;

2. Total bilirubin above 2 times the ULN or;

3. Serum creatinine above 1.5 times the ULN or;

4. Platelet count below 100 x 109/L or;

5. Hemoglobin below 4 mmol/L (females) or below 5 mmol/l (males);

6. Known positive test for human immunodeficiency virus (HIV), hepatitis B surface
antigen (HBsAG) or hepatitis C virus (HCV) antibody or patients with untreated
serious infections;

5. Patients pregnant or breastfeeding;

6. Any condition that the investigator considers to be potentially jeopardizing the
patient's well-being or the study objectives.