S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma
Status:
Completed
Trial end date:
2012-11-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
O6-benzylguanine may help carmustine kill more tumor cells by making tumor cells more
sensitive to the drug. It is not yet known whether radiation therapy and carmustine are more
effective with or without O6-benzylguanine.
PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy plus
carmustine with or without O6-benzylguanine in treating patients who have newly diagnosed
glioblastoma multiforme or gliosarcoma.