S. Endotoxin, Inflammatory Mediators and MRS Before and After Treatment in MHE

• Status: Completed
• Trial end date: 2012-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine S.endotoxins , inflammatory mediators and Magnetic Resonance Spectroscopy (MRS) before and after treatment in patients of cirrhosis and minimal hepatic encephalopathy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Govind Ballabh Pant Hospital
• Treatments: Lactulose

Criteria

Inclusion Criteria:

• Clinical diagnosis of Cirrhosis (Age 15 yr -70 yr )

Exclusion Criteria:

• Recent history of gastrointestinal bleed in last 6 weeks

• Active ongoing infection

• Creatinine >1.5mg%

• Electrolyte impairment. (S. Sodium < 130 meq/L, S. Potassium 3.5 meq/L or >5.0meq/L)

• H/O use of psychotropic drugs in last 6 weeks

• Recent alcohol use (< 6 week )

• H/O TIPS or shunt surgery.

• Hepatocellular Carcinoma

• Severe comorbidity as Congestive Heart Failure, Pulmonary disease, Neurological and Psychiatric problems impairing quality of life

• Poor vision precluding neuropsychological assessment