S. Boulardii in Prevention of Antibiotic-associated Diarrhea in Hospitalized Adults With Respiratory Tract Infections
Status:
Completed
Trial end date:
2018-12-31
Target enrollment:
Participant gender:
Summary
Antibiotic-associated diarrhea (AAD) is the most common gastrointestinal complication of
antibiotic use, with potentially serious clinical impact. The aim of this study is to assess
the efficacy and safety of Saccharomyces boulardii in the prevention of AAD in adult patients
with lower respiratory tract infection (LRTI) treated in a hospital.
A multicenter, randomized, parallel-group, double-blind, placebo-controlled study is
conducted whereby adults who are hospitalized due to LRTI and treated with intravenous
antibiotics and randomized to capsules containing S. boulardii or indistinguishable placebo.
The outcome measures were: relevant clinical features, gastrointestinal symptoms, and adverse
events.