Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite

• Status: Recruiting
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Clinicians tend to overuse antibiotics in snake bite despite evidence from three previous clinical trials that failed to show a benefit. But, none of these trials was done in India. Further, the species of snake in two of these trials was quite different from that seen in the Indian setting limiting generalization of these findings. Hence, home-grown evidence is needed to persuade clinicians to use antibiotics rationally.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jawaharlal Institute of Postgraduate Medical Education & Research
• Treatments: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Antibiotics, Antitubercular

Criteria

Inclusion Criteria:

• Age 18-65 years

• History of snake bite with features of local envenomation with/without systemic features

• Less than 24 hours since bite, AND

• No prior antibiotic treatment

Exclusion Criteria:

• Upper limb bites

• Multiple (> 1) bites

• Wound manipulation

• Extensive local necrosis or blebs

• Seriously-ill patients with hypotension/capillary leak/life threatening bleeding.

• Suspected cobra bite, OR

• Pregnant/breast-feeding women