Rosuvastatin Prevent Contrast Induced Acute Kidney Injury in Patients With Diabetes
Status:
Completed
Trial end date:
2011-11-01
Target enrollment:
Participant gender:
Summary
The number of cardiac angiography and percutaneous coronary interventions (PCI) has increased
steadily in recent years. This has resulted in the increasing incidence of contrast-induced
acute kidney injury (CIAKI). Major risk factors for CIAKI include older age, diabetes
mellitus (DM), chronic kidney disease(CKD), the concurrent use of nephrotoxic drugs,
hemodynamic instability, etc. Importantly, DM appears to act as a risk multiplier, meaning
that in a patient with CKD it amplifies the risk of CIAKI.
The aim of this multicenter prospective, randomized, controlled study is to evaluate whether
statins treatment during the perioperative period would reduce the risk of CIAKI in a
high-risk population of patients with both type 2 diabetes mellitus (T2DM) and CKD undergoing
coronary angiography or noncoronary angiography, and evaluate the influence of such potential
benefit on short-term outcome.